The Pioneers were outscored, 27-16, in the final quarter and lost in the first round of the NAIA Tournament on Wednesday.
MidAmerica Nazarene had a one-point lead heading into the fourth quarter, but Oklahoma City used a 13-6 run to open the stanza and went on to win, 73-63.
MNU finishes the season at 18-14.
Sophomore Whitney Moia led the way for the Pioneers with a double-double of 18 points and 10 rebounds on the day. Jovana Jovovic also scored 12.
Oklahoma City (30-2) also got a double-double from the NAIA’s leading scorer, Daniela Wallen, who put in 20 points to go with 10 boards.